How Does It Work? : Better Data Driving Better Decisions

How Does It Work?

General information about Open Flow Microperfusion, how it works and how it differs from Microdialysis Sampling.

Unlike a microdialysis probe, how does the cOFM sampling insert prevent damage to brain tissue while sampling?

The shaft of the cOFM guide is surrounded by brain tissue after implantation and the healing dummy inside the cOFM guide prevents in-growth of brain tissue d...

Fri, 3 Aug, 2018 at 11:16 AM

Unlike microdialysis, can I use the same animals for several intermittent sampling sessions over several days or weeks without creating tissue damage? For how long?

The healing dummy (secured by a locking wedge) can replace the cOFM sampling insert after sampling and animals can be returned to their home cages. When wor...

Fri, 3 Aug, 2018 at 11:23 AM

Can I sample neurotransmitters with cOFM?

Yes, cOFM allows sampling of hydrophilic to lipophilic substance regardless of molecular size. However, the whole setup (open length, flow rate, perfusion fl...

Fri, 3 Aug, 2018 at 11:25 AM

How tiny are the cOFM probes and can I use it for rats and mice?

cOFM probes can be used for rats and mice. Standard probes are available with different lengths and customized probes can be ordered at BASi. For more detai...

Fri, 3 Aug, 2018 at 11:29 AM

Do you offer cOFM contract research services?

Yes, JOANNEUM RESEARCH (JR) - HEALTH offers cOFM contract research services; based on broad experience, JR offers in vivo pre-clinical studies in animals (m...

Fri, 3 Aug, 2018 at 11:32 AM

Is there any loss of perfusate volume in the brain when using the cOFM probe with the OFM pump or some other peristaltic pump?

Volume loss is possible if the push rate is higher than the pull rate. For proper cOFM sampling, We highly recommends the use of an OFM pump which has guara...

Fri, 3 Aug, 2018 at 11:50 AM

How difficult is cOFM for a researcher experienced in small or large molecule microdialysis? Do I need any special hands-on training?

Special hands-on training with OFM specialists from JOANNEUM RESEARCH is recommended to improve research quality, but it is not a prerequisite. All products...

Fri, 3 Aug, 2018 at 12:01 PM

Do you have user manuals for OFM pumps and cOFM probes?

User manuals are delivered with products and are also available for download from the BASi website. Click here for cOFM probe user manual. Click here for...

Fri, 3 Aug, 2018 at 12:30 PM

When was the cOFM technology developed and how long has it been in use?

JOANNEUM RESEARCH began the development of OFM technology about 15 years ago. Due to the great success and the new demands for OFM products in clinical/ pre...

Fri, 3 Aug, 2018 at 12:35 PM