cOFM can be calibrated (=recovery estimation) for absolute quantification of substances in the brain. Influencing factors are the size of open length, flow rate, and perfusate composition. Additionally, the physical characteristics of the substance of interest can influence the recovery factor (e.g. adsorption to components of the cOFM system). ISF that is sampled by cOFM is diluted but the ISF composition is unchanged.
Is there a recovery factor for cOFM probes? What are the factors that influence recovery of molecules through cOFM probes in vivo? Is dilution of ISF a factor? Print
Modified on: Fri, 3 Aug, 2018 at 11:36 AM
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